In vitro activity of ceftriaxone alone and in combination with gentamicin, tobramycin, and amikacin against Pseudomonas aeruginosa.
نویسنده
چکیده
The in vitro activity of ceftriaxone alone and in combination with gentamicin, tobramycin, and amikacin against 50 Pseudomonas aeruginosa strains was studied by the broth dilution method and the time-kill curve method. The majority of the P. aeruginosa strains tested were resistant to ceftriaxone. Combining ceftriaxone with the aminoglycosides resulted in synergism, antagonism, or indifference.
منابع مشابه
Activity of newer aminoglycosides and carbenicillin, alone and in combination, against gentamicin-resistant Pseudomonas aeruginosa.
The in vitro activity of the aminoglycoside antibiotics tobramycin, sisomicin, amikacin, gentamicin, and netilmicin (SCH 20569) were compared against 26 gentamicin-resistant isolates of Pseudomonas aeruginosa cultured from hospitalized children. Tobramycin had the greatest activity on a weight basis, followed by sisomicin, gentamicin, amikacin, and netilmicin. All isolates were resistant to ach...
متن کاملActivity of Ceftriaxone Alone and in Combination with Gentamicin, Tobramycin, and Amikacin Against Pseudomonas aeruginosa
Ceftriaxone, a new third-generation cephalosporin with a very long serum half-life, has been shown to have a wide antimicrobial spectrum. Its activity against Pseudomonas aeruginosa, however, is rather limited (1, 5, 6, 8). The in vitro activity of ceftriaxone against 50 P. aeruginosa strains by the broth dilution method and the effects of combining ceftriaxone with gentamicin, tobramycin, or a...
متن کاملComparative activity of tobramycin, amikacin, and gentamicin alone and with carbenicillin against Pseudomonas aeruginosa.
The effect of gentamicin against 130 clinical isolates of Pseudomonas aeruginosa was compared with that of two investigational aminoglycoside antibiotics, tobramycin and amikacin. Minimal inhibitory concentration data indicated that, on a weight basis, tobramycin was two to four times as active as gentamicin against most isolates. However, 14 of 18 organisms highly resistant to gentamicin (>/=8...
متن کاملIn vitro susceptibility of gentamicin-resistant Enterobacteriaceae and Pseudomonas aeruginosa to netilmicin and selected aminoglycoside antibiotics.
Netilmicin (Sch 20569), a semisynthetic aminoglycoside related to gentamicin C(1a), was evaluated in vitro in agar dilution testing against 224 different clinical isolates of gentamicin-resistant Enterobacteriaceae and Pseudomonas aeruginosa in parallel with amikacin, gentamicin, sisomicin, and tobramycin. Netilmicin showed a very high degree of activity against gentamicin-resistant organisms, ...
متن کاملIn vitro activity of netilmicin compared with gentamicin, tobramycin, amikacin, and kanamycin.
The in vitro activity of netilmicin was compared with that of gentamicin, tobramycin, amikacin, and kanamycin against 636 strains of bacteria recently isolated from clinical sources. Gentamicin was the most active antibiotic, but netilmicin and tobramycin closely paralleled it. Netilmicin was generally four-to eightfold less active than gentamicin against Serratia and group A streptococci, and ...
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ورودعنوان ژورنال:
- Antimicrobial agents and chemotherapy
دوره 24 2 شماره
صفحات -
تاریخ انتشار 1983